NEOPLASIA In Vitro Evaluation of Fludarabine in Combination With Cyclophosphamide and / or Mitoxantrone in B-Cell Chronic Lymphocytic Leukemia

@inproceedings{Bellosillo1999NEOPLASIAIV,
  title={NEOPLASIA In Vitro Evaluation of Fludarabine in Combination With Cyclophosphamide and / or Mitoxantrone in B-Cell Chronic Lymphocytic Leukemia},
  author={Beatriz Bellosillo and Neus Villamor and Dolors Colomer and Gabriel Pons and Emili Montserrat and Joan Gil},
  year={1999}
}
B-chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of long-lived CD51 B lymphocytes. We have analyzed the effect in vitro of the combination of fludarabine with cyclophosphamide and/or mitoxantrone on cells from 20 B-CLL patients. Mafosfamide, the active form of cyclophosphamide in vitro, increased the cytotoxicity of fludarabine in all of the patients studied and produced a significant synergistic effect (P F .01) after 48 hours of incubation. The addition of… CONTINUE READING