NELL2 function in the protection of cells against endoplasmic reticulum stress.

@article{Kim2015NELL2FI,
  title={NELL2 function in the protection of cells against endoplasmic reticulum stress.},
  author={Dong Yeol Kim and Han Rae Kim and Kwang Kon Kim and Jeong Woo Park and Byung Ju Lee},
  journal={Molecules and cells},
  year={2015},
  volume={38 2},
  pages={
          145-50
        }
}
Continuous intra- and extracellular stresses induce disorder of Ca(2+) homeostasis and accumulation of unfolded protein in the endoplasmic reticulum (ER), which results in ER stress. Severe long-term ER stress triggers apoptosis signaling pathways, resulting in cell death. Neural epidermal growth factor-like like protein 2 (NELL2) has been reported to be important in protection of cells from cell death-inducing environments. In this study, we investigated the cytoprotective effect of NELL2 in… CONTINUE READING

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