NELL-1 in the treatment of osteoporotic bone loss

@inproceedings{James2015NELL1IT,
  title={NELL-1 in the treatment of osteoporotic bone loss},
  author={Aaron W James and Jia Si Shen and Xinli Zhang and Greg Asatrian and Raghav Goyal and Jin Hee Kwak and Lin Jiang and Benjamin C Bengs and Cymbeline T. Culiat and Anthony Simon Turner and Howard B. Seim and Benjamin M. Wu and Karen M Lyons and John S Adams and Kai-Ming Ting and Chia B Soo},
  booktitle={Nature communications},
  year={2015}
}
NELL-1 is a secreted, osteoinductive protein whose expression rheostatically controls skeletal ossification. Overexpression of NELL-1 results in craniosynostosis in humans and mice, whereas lack of Nell-1 expression is associated with skeletal undermineralization. Here we show that Nell-1-haploinsufficient mice have normal skeletal development but undergo age-related osteoporosis, characterized by a reduction in osteoblast:osteoclast (OB:OC) ratio and increased bone fragility. Recombinant NELL… CONTINUE READING
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