NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly.

Abstract

The Negative Elongation Factor (NELF) is a transcription regulatory complex that induces stalling of RNA polymerase II (Pol II) during early transcription elongation and represses expression of several genes studied to date, including Drosophila Hsp70, mammalian proto-oncogene junB, and HIV RNA. To determine the full spectrum of NELF target genes in… (More)
DOI: 10.1101/gad.1643208

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@article{Gilchrist2008NELFmediatedSO, title={NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly.}, author={Daniel A. Gilchrist and Sergei Nechaev and Chanhyo Lee and Saikat Ghosh and Jennifer Brady Collins and LePing Li and David S Gilmour and Karen Adelman}, journal={Genes & development}, year={2008}, volume={22 14}, pages={1921-33} }