NEK9-dependent proliferation of cancer cells lacking functional p53

@inproceedings{Kurioka2014NEK9dependentPO,
  title={NEK9-dependent proliferation of cancer cells lacking functional p53},
  author={Daisuke Kurioka and Fumitaka Takeshita and Koji Tsuta and Hiromi Sakamoto and Shun-ichi I. Watanabe and Kenji Akaiwa-shi Matsumoto and Masatoshi Watanabe and H. Bardessy N. Nakagama and Takahiro Ochiya and Jun Yokota and Takashi Kohno and Naoto Tsuchiya},
  booktitle={Scientific reports},
  year={2014}
}
Dysfunction of the p53 network is a major cause of cancer development, and selective elimination of p53-inactivated cancer cells therefore represents an ideal therapeutic strategy. In this study, we performed a microRNA target screen that identified NEK9 (NIMA-related kinase 9) as a crucial regulator of cell-cycle progression in p53-inactivated cancer cells. NEK9 depletion selectively inhibited proliferation in p53-deficient cancer cells both in vitro and in vivo. The resultant cell-cycle… CONTINUE READING
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