NEJ1 prevents NHEJ-dependent telomere fusions in yeast without telomerase.

  title={NEJ1 prevents NHEJ-dependent telomere fusions in yeast without telomerase.},
  author={Gianni Liti and Edward J Louis},
  journal={Molecular cell},
  volume={11 5},
In a search for genes involved in cell-type-dependent chromosome instability, we have found a role for NEJ1, a regulator of nonhomologous end joining (NHEJ), in cells that survive in the absence of telomerase. In yeast, NHEJ is regulated by mating-type status through NEJ1, which is repressed in a/alpha cells. For efficient NHEJ, NEJ1 is required as part of a complex with LIF1 and DNL4, which catalyzes DNA ligation. In haploid cells without telomerase, we find that the absence of NEJ1 results in… CONTINUE READING

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