NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae

  title={NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae},
  author={Mar{\'i}a de la Luz Valencia and Marc Bentele and Moreshwar B. Vaze and Gernot Herrmann and Eliayhu Kraus and Sang Eun Lee and Primo Sch{\"a}r and James E Haber},
Broken DNA ends are rejoined by non-homologous end-joining (NHEJ) pathways requiring the Ku proteins (Ku70, Ku80), DNA ligase IV and its associated protein Lif1/Xrcc4 (ref. 1). In mammalian meiotic cells, Ku protein levels are much lower than in somatic cells, apparently reducing the capacity of meiotic cells to carry out NHEJ and thereby promoting homologous recombination. In Saccharomyces cerevisiae, NHEJ is also downregulated in meiosis-competent MATa/MATα diploid cells in comparison with… CONTINUE READING
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