NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks.

  title={NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks.},
  author={Daniel McNeill and Manikandan Paramasivam and Jakita Baldwin and J Huang and Vaddadi N. Vyjayanti and Michael M. Seidman and David M Wilson},
  journal={The Journal of biological chemistry},
  volume={288 18},
Recent evidence suggests a role for base excision repair (BER) proteins in the response to DNA interstrand crosslinks, which block replication and transcription, and lead to cell death and genetic instability. Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks… CONTINUE READING
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