NEIL1 excises 3′ end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1

@article{Parsons2005NEIL1E3,
  title={NEIL1 excises 3′ end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1},
  author={Jason L. Parsons and Dmitry O. Zharkov and Grigory L Dianov},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={4849 - 4856}
}
Base excision repair is the major pathway for the repair of oxidative DNA damage in human cells that is initiated by a damage-specific DNA glycosylase. In human cells, the major DNA glycosylases for the excision of oxidative base damage are OGG1 and NTH1 that excise 8-oxoguanine and oxidative pyrimidines, respectively. We find that both enzymes have limited activity on DNA lesions located in the vicinity of the 3' end of a DNA single-strand break, suggesting that other enzymes are involved in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 25 REFERENCES

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL