NEIL1 Binding to DNA Containing 2′‐Fluorothymidine Glycol Stereoisomers and the Effect of Editing

@article{Onizuka2012NEIL1BT,
  title={NEIL1 Binding to DNA Containing 2′‐Fluorothymidine Glycol Stereoisomers and the Effect of Editing},
  author={Kazumitsu Onizuka and Jongchan Yeo and S. David and P. Beal},
  journal={ChemBioChem},
  year={2012},
  volume={13}
}
Thymine glycol (Tg), one of the oxidized bases formed in DNA by reactive oxygen species, is repaired by the DNA glycosylases such as NEIL1, NTH1 and Endo III. In our recent studies, we showed that NEIL1's catalytic efficiency and lesion specificity are regulated by an RNA‐editing adenosine deamination reaction. In this study, we synthesized oligodeoxynucleotides containing 2′‐fluorothymidine glycol with either ribo or arabino configuration and investigated the binding of these modified DNAs… Expand
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