NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN

@article{Wang2007NEDD41IA,
  title={NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN},
  author={X. Henry Wang and Lloyd C Trotman and Theresa M. Koppie and Andrea Alimonti and Zhenbang Chen and Zhonghua Gao and Junru Wang and Hediye Erdjument-Bromage and Paul Tempst and Carlos Cordon-Cardo and Pier Paolo Pandolfi and Xuejun Jiang},
  journal={Cell},
  year={2007},
  volume={128},
  pages={129-139}
}
The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis. Here we show that PTEN level is regulated by ubiquitin-mediated proteasomal degradation, and purified its ubiquitin ligase as HECT-domain protein NEDD4-1. In cells NEDD4-1 negatively regulates PTEN stability by catalyzing PTEN polyubiquitination. Consistent with the tumor… CONTINUE READING
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