NEDD4: a promising target for cancer therapy.

  title={NEDD4: a promising target for cancer therapy.},
  author={Xiantao Ye and Lixia Wang and Bingxue Shang and Zhiwei Wang and Wenyi Wei},
  journal={Current cancer drug targets},
  volume={14 6},
The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development and progression of human cancers. In this review, to understand the regulatory mechanism(s) of NEDD4 as well as the signaling pathways controlled by NEDD4, we briefly describe the NEDD4 upstream regulators and its downstream ubiquitin substrates. Moreover, we further discuss its oncogenic roles in human malignancies… CONTINUE READING