NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma.

@article{Lai2016NDUFA4L2FO,
  title={NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma.},
  author={Robin Lai and Iris Ming-jing Xu and David Kung-Chun Chiu and Aki Pui-Wah Tse and Larry Lai Wei and Cheuk-Ting Law and D. W. K. Lee and Chun-Ming Wong and Maria Pik Wong and Irene Oi-lin Ng and Carmen Chak-lui Wong},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2016},
  volume={22 12},
  pages={
          3105-17
        }
}
PURPOSE Hepatocellular carcinoma (HCC) lacks effective curative therapy. Hypoxia is commonly found in HCC. Hypoxia elicits a series of protumorigenic responses through hypoxia-inducible factor-1 (HIF1). Better understanding of the metabolic adaptations of HCC cells during hypoxia is essential to the design of new therapeutic regimen. EXPERIMENTAL DESIGN Expressions of genes involved in the electron transport chain (ETC) in HCC cell lines (20% and 1% O2) and human HCC samples were analyzed by… CONTINUE READING
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