NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons.

@article{Vaes2017NDRG4AE,
  title={NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons.},
  author={Nathalie Vaes and Marjolein H. F. M. Lentjes and Marion J. J. Gijbels and Glenn Rademakers and Kathleen L J Daenen and Werend Boesmans and Kim A. D. Wouters and A Geuzens and Xianghu Qu and Hellen P Steinbusch and Bart P. F. Rutten and Scott H Baldwin and Keith A. Sharkey and Robert M. W. Hofstra and Manon van Engeland and Pieter Vanden Berghe and V Melotte},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2017},
  volume={29 9}
}
BACKGROUND Promoter methylation of N-myc Downstream-Regulated Gene 4 (NDRG4) in fecal DNA is an established early detection marker for colorectal cancer (CRC). Despite its connection to CRC, NDRG4 is predominantly studied in brain and heart, with little to no knowledge about its expression or role in other organs. In this study, we aimed to determine the… CONTINUE READING