NDRG2-mediated Modulation of SOCS3 and STAT3 Activity Inhibits IL-10 Production

  title={NDRG2-mediated Modulation of SOCS3 and STAT3 Activity Inhibits IL-10 Production},
  author={Eun Byul Lee and Aeyung Kim and Kyeongah Kang and Hyeree Kim and Jong-Seok Lim},
  booktitle={Immune network},
BACKGROUND N-myc downstream regulated gene 2 (NDRG2) is a member of the NDRG gene family. Our previous report indicated a possible role for NDRG2 in regulating the cytokine, interleukin-10 (IL-10), which is an important immunosuppressive cytokine. Several pathways, including p38-MAPK, NF-κB, and JAK/STAT, are used for IL-10 production, and the JAK/STAT… CONTINUE READING

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