NDE1 and GSK3β Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking.

@article{Ogawa2016NDE1AG,
  title={NDE1 and GSK3β Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking.},
  author={Fumiaki Ogawa and Laura C Murphy and Elise L.V. Malavasi and Shane T O'Sullivan and Helen Scott Torrance and David J. Porteous and Jessica K Millar},
  journal={ACS chemical neuroscience},
  year={2016},
  volume={7 5},
  pages={
          553-64
        }
}
Mitochondria are essential for neuronal function, providing the energy required to power neurotransmission, and fulfilling many important additional roles. In neurons, mitochondria must be efficiently transported to sites, including synapses, where their functions are required. Neurons, with their highly elongated morphology, are consequently extremely sensitive to defective mitochondrial trafficking which can lead to neuronal ill-health/death. We recently demonstrated that DISC1 associates… CONTINUE READING