NCX as a key player in the neuroprotection exerted by ischemic preconditioning and postconditioning.

@article{Pignataro2013NCXAA,
  title={NCX as a key player in the neuroprotection exerted by ischemic preconditioning and postconditioning.},
  author={Giuseppe Pignataro and Ornella Cuomo and Antonio Vinciguerra and Rossana Sirabella and Elga Esposito and Francesca Boscia and Gianfranco Maria Di Renzo and Leonardo R. A. Annunziato},
  journal={Advances in experimental medicine and biology},
  year={2013},
  volume={961},
  pages={
          223-40
        }
}
Ischemic preconditioning is a neuroprotective mechanism in which a brief non-injurious episode of ischemia protects the brain from a subsequent lethal insult. Recently, it has been reported that modified reperfusion subsequent to a prolonged ischemic episode may also confer neuroprotection, a phenomenon termed postconditioning. Mitogen-activated protein kinases (MAPK) play a key role in these two neuroprotective mechanisms. The aim of this study was to evaluate whether Na(+)/Ca(2+) exchangers… CONTINUE READING
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VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 82 REFERENCES

Ischemic post-conditioning: a new neuroprotective strategy (Society for Neuroscience, Atlanta

G. Pignataro, Z. Xiong, R. P. Simon
  • 2006
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Realizing the clinical potential of ischemic preconditioning and postconditioning

  • Nature Clinical Practice Cardiovascular Medicine
  • 2005
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Two new effectors of delayed preconditioning in brain ischemia

N. Blondeau Plamondon, C. Heurteaux, M. Lazdunski
  • Neurobiol . Dis .
  • 2012

The NCX 3 isoform of the Na + / Ca 2 + exchanger contributes to neuroprotection elicited by ischemic postcondi - tioning

L. Annunziato G. Di Renzo
  • J . Cereb . Blood Flow Metab .
  • 2011

Control of the Na + / Ca 2 + exchanger 3 promoter by cyclic adenosine monophosphate and Ca 2 + in differentiating neurons

S. Bortoluzzi Gabellini, G. A. Danieli, E. Carafoli
  • Mol . Pharmacol .
  • 2008

Ischemic post - conditioning protects against global cerebral ischemia / reperfusion - induced injury in rats

N. Arbez Willaime-Morawek, J. Mariani, B. Brugg
  • 2008