NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide.

@article{Fiorucci2002NCX4016I,
  title={NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide.},
  author={Stefano Fiorucci and Andrea Mencarelli and Alessandra Meneguzzi and Alessandro Lechi and Antonio Morelli and Piero del Soldato and Pietro Minuz},
  journal={Circulation},
  year={2002},
  volume={106 24},
  pages={3120-5}
}
BACKGROUND NCX-4016 is an acetylsalicylic acid (ASA) derivative containing a nitric oxide-releasing moiety. Compared with ASA, NCX-4016 has a broader spectrum of antithrombotic and antiinflammatory activities. We hypothesized that NCX-4016 might inhibit in vivo lipopolysaccharide (LPS)-induced expression of tissue factor (TF). METHODS AND RESULTS Rats were administered 90 mg/kg NCX-4016 orally for 5 days. Placebo, 50 mg/kg ASA, and 80 mg/kg isosorbide-5-mononitrate (ISMN) were used in control… CONTINUE READING
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Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice

  • C Napoli, G Cirino, P Del Soldato
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