NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory

@article{Saab2009NCS1IT,
  title={NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory},
  author={Bechara John Saab and John Georgiou and Arup R. Nath and Frank J S Lee and Min Wang and Aubin Michalon and Fang Liu and Isabelle M. Mansuy and John C. Roder},
  journal={Neuron},
  year={2009},
  volume={63},
  pages={643-656}
}
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TLDR
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The Role of δ Subunit-containing γ-aminobutyric Acid Type A Receptors in Memory and Synaptic Plasticity
TLDR
It was postulated that δGABAA receptors regulate memory and neurogenesis in the DG and pre-treatment with THIP improved memory in WT but not Gabrd–/– mice, and impaired object-place recognition, novel object recognition and contextual discrimination relative to WT mice.
Current Understanding of the Role of Neuronal Calcium Sensor 1 in Neurological Disorders
TLDR
The therapeutic potential of manipulating the interaction of NCS-1 with its many targets is identified and directions for future research on the role of N CS-1 in diseases such as schizophrenia and bipolar disorder are suggested.
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