NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory

@article{Saab2009NCS1IT,
  title={NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory},
  author={Bechara John Saab and John Georgiou and Arup R. Nath and F. J. Lee and M. Wang and A. Michalon and Fang Liu and I. Mansuy and J. Roder},
  journal={Neuron},
  year={2009},
  volume={63},
  pages={643-656}
}
  • Bechara John Saab, John Georgiou, +6 authors J. Roder
  • Published 2009
  • Psychology, Medicine
  • Neuron
  • The molecular underpinnings of exploration and its link to learning and memory remain poorly understood. Here we show that inducible, modest overexpression of neuronal calcium sensor 1 (Ncs1) selectively in the adult murine dentate gyrus (DG) promotes a specific form of exploratory behavior. The mice also display a selective facilitation of long-term potentiation (LTP) in the medial perforant path and a selective enhancement in rapid-acquisition spatial memory, phenotypes that are reversed by… CONTINUE READING
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    References

    SHOWING 1-10 OF 97 REFERENCES
    Hormonal and monoamine signaling during reinforcement of hippocampal long-term potentiation and memory retrieval.
    • 40
    • PDF
    Ca2+ Signaling via the Neuronal Calcium Sensor-1 Regulates Associative Learning and Memory in C. elegans
    • 229
    Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network
    • 766
    • PDF
    A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis
    • 415
    Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats
    • 156
    Hippocampal synaptic enhancement and information storage within a distributed memory system
    • 1,160