NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory

@article{Saab2009NCS1IT,
  title={NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory},
  author={Bechara John Saab and John Georgiou and Arup R. Nath and Frank J S Lee and Min Wang and Aubin Michalon and Fang Liu and Isabelle M. Mansuy and John C. Roder},
  journal={Neuron},
  year={2009},
  volume={63},
  pages={643-656}
}
The molecular underpinnings of exploration and its link to learning and memory remain poorly understood. Here we show that inducible, modest overexpression of neuronal calcium sensor 1 (Ncs1) selectively in the adult murine dentate gyrus (DG) promotes a specific form of exploratory behavior. The mice also display a selective facilitation of long-term potentiation (LTP) in the medial perforant path and a selective enhancement in rapid-acquisition spatial memory, phenotypes that are reversed by… Expand
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  • Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2021
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References

SHOWING 1-10 OF 99 REFERENCES
Hormonal and monoamine signaling during reinforcement of hippocampal long-term potentiation and memory retrieval.
TLDR
It is suggested that beta-adrenergic receptor activation is the main signaling system required for the retrieval of spatial memory and the data provide evidence for similar integrative interactions between different signaling systems during cellular memory processes. Expand
Regulated expression of the neuronal calcium sensor-1 gene during long-term potentiation in the dentate gyrus in vivo
TLDR
Results show that regulated expression of the NCS-1 gene is part of the transcriptional response associated with activity-dependent neuronal plasticity in vivo and suggest a molecular mechanism capable of mediating a functional change in synapse sensitivity to calcium and calcium-signalling pathways after long-term potentiation. Expand
Ca2+ Signaling via the Neuronal Calcium Sensor-1 Regulates Associative Learning and Memory in C. elegans
TLDR
It is shown that the neuron-specific calcium sensor-1 (NCS-1) is essential for optimal IT, and proper calcium signaling via NCS-1 defines a novel pathway essential for associative learning and memory. Expand
Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin
TLDR
It is found that the transient reduction of calcineurin activity facilitates LTP in vitro and in vivo and is accompanied by enhanced learning and strengthened short- and long-term memory in several hippocampal-dependent spatial and nonspatial tasks. Expand
Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network
TLDR
Evidence is provided that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation, by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1 in dentates gyrus granule Cells. Expand
Regulation of depotentiation and long-term potentiation in the dentate gyrus of freely moving rats by dopamine D2-like receptors.
TLDR
A specific role for dopamine D2-like receptors in the regulation of both depotentiation and LTP in vivo is suggested and an important and novel insight is offered as to the involvement of these receptors in processes related to learning and memory. Expand
Involvement of dopamine D2 receptors in the induction of long-term potentiation in the basolateral amygdala–dentate gyrus pathway of anesthetized rats
TLDR
The results suggest that the D2-dopaminergic system, but not the beta-adrenergic, muscarinic or D1-doperative system, is involved in the induction of BLA-DG LTP, which is likely to be a valuable model for elucidating neural mechanisms linking emotion and memory. Expand
A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis
TLDR
Whether specific subregions (dentate gyrus, CA3, and CA1) of the hippocampus provide unique contributions to specific processes associated with intrinsic information processing exemplified by novelty detection, encoding, pattern separation, pattern association, pattern completion, retrieval, short-term memory and intermediate- term memory is determined. Expand
Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats
TLDR
Clear evidence is provided that hippocampal D2 activity is positively related to working memory performance, while evidence for D1 systems is less compelling. Expand
Functional regulation of the dentate gyrus by GABA-mediated inhibition.
TLDR
Both synaptic and extrasynaptic GABA(A) receptors exhibit profound dysregulation in animal models of temporal lobe epilepsy, which may contribute to the hippocampal hyperexcitability that defines this disorder. Expand
...
1
2
3
4
5
...