NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory

  title={NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory},
  author={Bechara John Saab and John Georgiou and Arup R. Nath and Frank J S Lee and Min Wang and Aubin Michalon and Fang Liu and Isabelle M. Mansuy and John C. Roder},
The Synaptic Role of Neuronal Calcium Sensor 1 in Dentate Gyrus Plasticity, Curiosity and Spatial Memory
It is proposed that the generation of curiosity is a fundamental feature of the nervous system and is upstream of learning and cognition, as such, molecular cascades involved in curiosity likely also play roles in mental illnesses.
Dopamine D2R is Required for Hippocampal-dependent Memory and Plasticity at the CA3-CA1 Synapse
The results demonstrate the first direct evidence that D2R is essential in behaving mice for trace eye blink conditioning and associated changes in hippocampal synaptic strength, indicating a key role of D1R in regulating hippocampal plasticity changes and, in consequence, acquisition and consolidation of spatial and associative forms of memory.
Self-directed exploration provides a Ncs1-dependent learning bonus
It is shown for the first time in a non-primate species, that spatial learning receives a special bonus from self-directed exploration when exploration is escape-oriented, or when the full repertoire of exploratory behaviors is reduced, no learning bonus occurs.
Possible Signaling Pathways Mediating Neuronal Calcium Sensor-1-Dependent Spatial Learning and Memory in Mice
The findings indicate that NCS-1 may regulate spatial learning and memory function at least in part through activation of CaMKII-α signaling, which may directly or indirectly increase BDNF production.
Characterization of dopamine D1 and D2 receptor‐expressing neurons in the mouse hippocampus
The results demonstrate that D1 and D2 receptor‐expressing neurons are strictly segregated in the mouse hippocampus, and establishes a basis for future investigations aiming at elucidating their roles in the hippocampal network.
Ca2+-Binding Protein 1 Regulates Hippocampal-dependent Memory and Synaptic Plasticity
Specific Role for GSK3α in Limiting Long-Term Potentiation in CA1 Pyramidal Neurons of Adult Mouse Hippocampus
H hippocampal slices obtained from adult mice were used to determine the role of each paralog in CA3−CA1 long-term potentiation (LTP) of synaptic transmission, a form of plasticity critically required in learning and memory.
The Role of δ Subunit-containing γ-aminobutyric Acid Type A Receptors in Memory and Synaptic Plasticity
It was postulated that δGABAA receptors regulate memory and neurogenesis in the DG and pre-treatment with THIP improved memory in WT but not Gabrd–/– mice, and impaired object-place recognition, novel object recognition and contextual discrimination relative to WT mice.
Current Understanding of the Role of Neuronal Calcium Sensor 1 in Neurological Disorders
The therapeutic potential of manipulating the interaction of NCS-1 with its many targets is identified and directions for future research on the role of N CS-1 in diseases such as schizophrenia and bipolar disorder are suggested.


Hormonal and monoamine signaling during reinforcement of hippocampal long-term potentiation and memory retrieval.
It is suggested that beta-adrenergic receptor activation is the main signaling system required for the retrieval of spatial memory and the data provide evidence for similar integrative interactions between different signaling systems during cellular memory processes.
Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network
Evidence is provided that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation, by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1 in dentates gyrus granule Cells.
Regulation of depotentiation and long-term potentiation in the dentate gyrus of freely moving rats by dopamine D2-like receptors.
A specific role for dopamine D2-like receptors in the regulation of both depotentiation and LTP in vivo is suggested and an important and novel insight is offered as to the involvement of these receptors in processes related to learning and memory.
A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis
Whether specific subregions (dentate gyrus, CA3, and CA1) of the hippocampus provide unique contributions to specific processes associated with intrinsic information processing exemplified by novelty detection, encoding, pattern separation, pattern association, pattern completion, retrieval, short-term memory and intermediate- term memory is determined.
Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats
Functional regulation of the dentate gyrus by GABA-mediated inhibition.