NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory

  title={NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory},
  author={Bechara John Saab and John Georgiou and Arup R. Nath and F. J. Lee and M. Wang and A. Michalon and Fang Liu and I. Mansuy and J. Roder},
  • Bechara John Saab, John Georgiou, +6 authors J. Roder
  • Published 2009
  • Psychology, Medicine
  • Neuron
  • The molecular underpinnings of exploration and its link to learning and memory remain poorly understood. Here we show that inducible, modest overexpression of neuronal calcium sensor 1 (Ncs1) selectively in the adult murine dentate gyrus (DG) promotes a specific form of exploratory behavior. The mice also display a selective facilitation of long-term potentiation (LTP) in the medial perforant path and a selective enhancement in rapid-acquisition spatial memory, phenotypes that are reversed by… CONTINUE READING
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