NCR(+)ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures.

@article{Carrega2015NCRILC3CI,
  title={NCR(+)ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures.},
  author={Paolo Carrega and Fabrizio Loiacono and Emma Di Carlo and Angelo Scaramuccia and Marco Mora and Romana Conte and Roberto Benelli and Grazia Maria Spaggiari and Claudia Cantoni and Stefania Campana and Irene Bonaccorsi and Barbara Morandi and Mauro Truini and Maria Cristina Mingari and Lorenzo Moretta and Guido Ferlazzo},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={8280}
}
Tertiary lymphoid structures (TLSs) are a common finding in non-small cell lung cancer (NSCLC) and are predictors of favourable clinical outcome. Here we show that NCR(+) innate lymphoid cell (ILC)-3 are present in the lymphoid infiltrate of human NSCLC and are mainly localized at the edge of tumour-associated TLSs. This intra-tumoral lymphocyte subset is… CONTINUE READING