NCI Image-Guided Drug Delivery Summit.

@article{Tandon2011NCIID,
  title={NCI Image-Guided Drug Delivery Summit.},
  author={Pushpa Tandon and Keyvan Farahani},
  journal={Cancer research},
  year={2011},
  volume={71 2},
  pages={
          314-7
        }
}
On April 17, 2010, scientists from academia, the National Cancer Institute (NCI), and the Food and Drug Administration (FDA) assembled at "The NCI Image Guided Drug Delivery Summit," in Washington D.C., to discuss recent advances, barriers, opportunities, and regulatory issues related to the field. The meeting included a scientific session and an NCI/FDA session, followed by a panel discussion of speakers from both sessions. Image-guided drug delivery (IGDD) in cancer is a form of… 
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References

SHOWING 1-10 OF 17 REFERENCES
Targeting the efficacy of a dendrimer-based nanotherapeutic in heterogeneous xenograft tumors in vivo
TLDR
The animal model of the artificial heterogeneous xenograft tumor showed that the nanotherapeutic was preferentially cytotoxic to KB cells, and the large-scale synthesis of a G5-FA-MTX conjugate was evaluated for its cytotoxicity potential and specificity.
Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature.
TLDR
The effects of a range of temperatures and hyperthermia treatment scheduling on the extravasation of nanoparticles from tumor microvasculature in a human tumor (SKOV-3 ovarian carcinoma) xenograft grown in athymic nude mouse window chambers are investigated.
Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes.
TLDR
A different expression strategy for the anti-TfR scFv, which produces high levels of protein without any tags, and a different approach for complexing the targeting scFV to the liposomes, which provides a promising system for tumor-targeted gene delivery that may have potential for systemic gene therapy of various human cancers.
In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes.
TLDR
High targeting specificity and benign biological response establish this nanoprobe as a potential platform to aid in the diagnosis and treatment of gliomas and other tumors of neuroectodermal origin.
Designed Auto-assembly of Nanostreptabodies for Rapid Tissue-specific Targeting in Vivo*
TLDR
This work generates nanostructures called nanostreptabodies by controlled sequential assembly of biotin-engineered antibody fragments on a streptavidin scaffold with a defined capacity for additional biotinylated payloads such as other antibodies to create bispecific antibodies as well as organic and non-organic moieties.
Molecular MR imaging of melanoma angiogenesis with ανβ3‐targeted paramagnetic nanoparticles
TLDR
The present study lowers the limit previously reported for detecting sparse biomarkers with molecular MRI in vivo, and may be employed to noninvasively detect very small regions of angiogenesis associated with nascent melanoma tumors, and to phenotype and stage early melanoma in a clinical setting.
Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung
TLDR
'In vivo proteomic imaging' as described here integrates organellar proteomics with multiple imaging techniques to identify an accessible target space that includes the transvascular pumping space of the caveola, and shows rapid, specific delivery into lung well beyond that achieved by standard vascular targeting.
Image-guided, noninvasive, spatiotemporal control of gene expression
TLDR
The combination of MRI-guided HIFU heating and transgenes under control of heat-inducible HSP promoter provides a direct, noninvasive, spatial control of gene expression via local hyperthermia.
...
...