NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn).

@article{Beggs1997NCAM140IW,
  title={NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn).},
  author={Hilary E. Beggs and S C Baragona and John J. Hemperly and Patricia F. Maness},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 13},
  pages={8310-9}
}
Axonal growth cones respond to adhesion molecules and extracellular matrix components by rapid morphological changes and growth rate modification. Neurite outgrowth mediated by the neural cell adhesion molecule (NCAM) requires the src family tyrosine kinase p59(fyn) in nerve growth cones, but the molecular basis for this interaction has not been defined. The NCAM140 isoform, which is found in migrating growth cones, selectively co-immunoprecipitated with p59(fyn) from nonionic detergent (Brij… CONTINUE READING
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