NCAM-induced neurite outgrowth depends on binding of calmodulin to NCAM and on nuclear import of NCAM and fak fragments.

@article{Kleene2010NCAMinducedNO,
  title={NCAM-induced neurite outgrowth depends on binding of calmodulin to NCAM and on nuclear import of NCAM and fak fragments.},
  author={Ralf Kleene and Mounir Mzoughi and Gunjan Joshi and Ina Kalus and Ulrich Bormann and Christian Schulze and Mei-Fang Xiao and Alexander Dityatev and Melitta Schachner},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 32},
  pages={10784-98}
}
The neural cell adhesion molecule NCAM plays important functional roles not only during nervous system development, but also in the adult after injury and in synaptic plasticity. Homophilic binding of NCAM triggers intracellular signaling events resulting in cellular responses such as neurite outgrowth that require NCAM palmitoylation-dependent raft localization and activation of the nonreceptor tyrosine kinases fyn and fak. In this study, we show that stimulation of NCAM by a function… CONTINUE READING
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