NC381, a novel anticancer agent, arrests the cell cycle in G0-G1 and inhibits lung tumor cell growth in vitro and in vivo.

@article{Cao2004NC381AN,
  title={NC381, a novel anticancer agent, arrests the cell cycle in G0-G1 and inhibits lung tumor cell growth in vitro and in vivo.},
  author={Ming-yu Cao and Yoon Azalea Lee and Ning-ping Feng and Raed A. Al-Qawasmeh and St{\'e}phane Viau and X. P. Gu and Leo W. M. Lau and Hongnan Jin and Ming Wang and A. Vassilakos and Jim A. Wright and Aiping H. Young},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={308 2},
  pages={538-46}
}
Although clotrimazole (CLT), an antifungal drug, inhibits tumor cell proliferation and angiogenesis, its clinical application is hampered by significant hepatotoxicity due to the presence of an imidazole moiety. In our attempts to develop CLT analogs that are devoid of imidazole and are as efficacious as CLT, one pharmacophore designated NC381 was generated… CONTINUE READING