NASPE young investigator awardee-1990. Complex rhythms resulting from overdrive suppression in electrically stimulated heart cell aggregates.

Abstract

Spontaneously beating embryonic chick heart cell aggregates were stimulated with current pulses delivered either as periodic trains, or at a fixed delay after each action potential. Following stimulation at fixed rates faster than the intrinsic rate, there was a transient slowing of the spontaneous rhythm. This response, called overdrive suppression, can lead to a complex evolution of rhythms. During periodic stimulation there is a continuum of dropped beat patterns, and during fixed delay stimulation bursting activity appears. This study provides a conceptual basis for understanding analogous rhythms in the intact heart.

Cite this paper

@article{Wanzhen1990NASPEYI, title={NASPE young investigator awardee-1990. Complex rhythms resulting from overdrive suppression in electrically stimulated heart cell aggregates.}, author={Z Wanzhen and Joske Morissette and Richard M. Brochu and Leon Glass and Alvin Shrier}, journal={Pacing and clinical electrophysiology : PACE}, year={1990}, volume={13 12 Pt 1}, pages={1678-85} }