NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).

@article{Yamada2006NARFAN,
  title={NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).},
  author={Misato Yamada and Junji Ohnishi and Bisei Ohkawara and Shunichiro Iemura and Kiyotoshi Satoh and Junko Hyodo-Miura and Kaoru Kawachi and Tohru Natsume and H. Shibuya},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 30},
  pages={20749-60}
}
beta-Catenin is a key player in the Wnt signaling pathway, and interacts with cofactor T cell factor/lymphoid enhancer factor (TCF/LEF) to generate a transcription activator complex that activates Wnt-induced genes. We previously reported that Nemo-like kinase (NLK) negatively regulates Wnt signaling via phosphorylation of TCF/LEF. To further evaluate the physiological roles of NLK, we performed yeast two-hybrid screening to identify NLK-interacting proteins. From this screen, we isolated a… CONTINUE READING
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