NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model

@article{Shiryaev2009NAPPM,
  title={NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model},
  author={Natalia Shiryaev and Yan Jouroukhin and Eliezer Giladi and Eleni Polyzoidou and Illana Gozes},
  journal={Neurobiology of Disease},
  year={2009},
  volume={34},
  pages={381-388}
}
NAP (NAPVSIPQ) provides broad neuroprotection through microtubule interaction. Here, NAP was investigated for neuroprotection in an in vivo tauopathy model. Transgenic mice (2-month-old) that express the human double mutant tau protein [P301S;K257T] fused to the tau promoter, were subjected to daily intranasal drug treatment for approximately 5 months. Results showed increased performance in the NAP-treated mice compared to controls, as demonstrated in the Morris water maze, (p<0.05). Treatment… CONTINUE READING

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