NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death.

@article{Leker2002NAPAF,
  title={NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death.},
  author={Ronen Robert Leker and Angella Teichner and Nikolas Grigoriadis and Haim Ovadia and Douglas E. Brenneman and Mati Fridkin and Eli Giladi and J. Foro Romano and Illana Gozes},
  journal={Stroke},
  year={2002},
  volume={33 4},
  pages={1085-92}
}
BACKGROUND AND PURPOSE We sought to determine the cerebroprotective potential of NAP, a synthetic octapeptide related to vasoactive intestinal peptide. Activity-dependent neuroprotective protein mediates some of the protective effects of vasoactive intestinal peptide. The neuroprotective NAP sequence is derived from activity-dependent neuroprotective protein. METHODS Spontaneously hypertensive rats underwent permanent middle cerebral artery occlusion by craniotomy and electrocoagulation… CONTINUE READING
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