Corpus ID: 55625724

NANOVEHICLES: AN EFFICIENT CARRIER FOR ACTIVE MOLECULES FOR ENTRY INTO THE CELL

@inproceedings{Pattnaik2010NANOVEHICLESAE,
  title={NANOVEHICLES: AN EFFICIENT CARRIER FOR ACTIVE MOLECULES FOR ENTRY INTO THE CELL},
  author={Gurudatta Pattnaik and K. Raju and B. Heeralal},
  year={2010}
}
Nanovehicle as a carriers offer exclusive possibilities to overwhelmed cellular obstruction in order to improve the delivery of active substances, including the promising therapeutic biomacromolecules (i.e., nucleic acids, proteins). There are number of mechanisms lead to nanocarrier cellular internalization that is desperately affected by nanoparticles’ physicochemical properties. The pharmacological actions of nanocarriers may be depends on the different paths cellular uptake and… Expand

Figures and Tables from this paper

Subcellular drug targeting, pharmacokinetics and bioavailability
  • S. Leucuţa
  • Medicine, Chemistry
  • Journal of drug targeting
  • 2014
TLDR
It is expected that intracellularly targeted drug delivery approaches will be clinically useful using specialized DDSs belonging to the pharmaceutical nanotechnologies. Expand
The targeting properties of folate-conjugated Pluronic F127/poly (lactic-co-glycolic) nanoparticles.
TLDR
In vitro cytotoxicity studies demonstrated that the in vitro antitumor effect of PTX could be improved by encapsulating PTX into PLGA-F127-PLGA nanoparticles, and in vivo pharmacokinetic studies indicated that FA-F 127-PL GA nanoparticles prolong the circulation time ofPTX in plasma, and delay the blood clearance of PTx. Expand
Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies
TLDR
Fe3O4-PEI-RITC MNPs combined MR-fluorescence imaging capabilities with additional potential for transfection applications can provide a powerful tool, after further development, for non-invasive cell tracking and gene transfer to neural transplant populations. Expand

References

SHOWING 1-10 OF 41 REFERENCES
Nanocarriers’ entry into the cell: relevance to drug delivery
TLDR
This review will discuss nanocarriers able to deliver anticancer agents, nucleic acids, proteins and peptides for therapeutic applications by these non-phagocytic routes, starting with the phagocytosis pathway. Expand
Targeting of nanoparticles to the clathrin-mediated endocytic pathway.
TLDR
The addition of a positive charge to NPs may improve their potential as nanoparticulate carriers for drug delivery and enhance their ability to internalize into mammalian cells. Expand
Biodegradable nanoparticles for cytosolic delivery of therapeutics.
TLDR
The present review discusses the various aspects of the studies and emphasizes the need for understanding of the molecular mechanisms of intracellular trafficking of nanoparticles in order to develop an efficient cytosolic delivery system. Expand
Nanoparticles as microcarriers for anticancer drugs
Abstract This paper surveys the current status of anticancer drug delivery by means of polyalkylcyanoacrylate nanoparticles. In spite of the development of numerous antineoplastic drugs, no idealExpand
Endocytic mechanisms for targeted drug delivery.
TLDR
Current work is investigating a synthetic receptor approach for high affinity binding of targeted macromolecules to the endolysosomal pathway, which has serious potential for improving drug delivery for the treatment of lysosomal storage diseases, cancer, and Alzheimer's disease. Expand
Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells.
The interactions between various functionalized carbon nanotubes and several types of human cancer cells are explored. We have prepared modified nanotubes and have shown that these can be derivatizedExpand
The exploitation of differential endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate chemotherapeutic agents.
TLDR
Major difference in interactions of cl-micelles with cancer and normal cells that can lead to development of novel drug delivery system with reduced side effects and higher efficacy in cancer chemotherapy are described. Expand
Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis.
TLDR
The data indicate that the size itself of (ligand-devoid) particles can determine the pathway of entry in non-phagocytic B16 cells, and kinetic parameters may determine the almost exclusive internalization of such particles along this pathway rather than via caveolae. Expand
Mechanisms of quantum dot nanoparticle cellular uptake.
TLDR
It is shown that QD with a carboxylic acid surface coating were recognized by lipid rafts but not by clathrin or caveolae in human epidermal keratinocytes (HEKs) and endocytic pathways are primarily regulated by the G-protein-coupled receptor associated pathway and low density lipoprotein receptor/scavenger receptor. Expand
The effects of liposome size and surface charge on liposome-mediated delivery of methotrexate-gamma-aspartate to cells in vitro.
TLDR
The liposome-mediated delivery of methotrexate-gamma-aspartate to five cell lines is studied, suggesting an endocytic mechanism for delivery and the potency of the encapsulated drug is not affected by wide variations in the drug: lipid ratio. Expand
...
1
2
3
4
5
...