NANOG reprograms prostate cancer cells to castration resistance via dynamically repressing and engaging the AR/FOXA1 signaling axis

@inproceedings{Jeter2016NANOGRP,
  title={NANOG reprograms prostate cancer cells to castration resistance via dynamically repressing and engaging the AR/FOXA1 signaling axis},
  author={Collene R. Jeter and Bigang Liu and Yue Lu and Hsueh-Ping Chao and Dingxiao Zhang and Xin Liu and Xin Mao Chen and Qiuhui Li and Kiera Rycaj and Tammy Calhoun-Davis and Li Yan and Qiang Hu and Jianmin Wang and Jianjun Shen and Song Liu and Dean G Tang},
  booktitle={Cell Discovery},
  year={2016}
}
The pluripotency transcription factor NANOG has been implicated in tumor development, and NANOG-expressing cancer cells manifest stem cell properties that sustain tumor homeostasis, mediate therapy resistance and fuel tumor progression. However, how NANOG converges on somatic circuitry to trigger oncogenic reprogramming remains obscure. We previously reported that inducible NANOG expression propels the emergence of aggressive castration-resistant prostate cancer phenotypes. Here we first show… CONTINUE READING