NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF‐Dependent Gene Expression

@article{Mistriotis2017NANOGRT,
  title={NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF‐Dependent Gene Expression},
  author={P. Mistriotis and V. Bajpai and Xiaoyan Wang and Na Rong and A. Shahini and Mohammadnabi Asmani and Mao-shih Liang and Jianmin Wang and P. Lei and Song Liu and Ruogang Zhao and S. Andreadis},
  journal={STEM CELLS},
  year={2017},
  volume={35}
}
Cellular senescence as a result of organismal aging or progeroid diseases leads to stem cell pool exhaustion hindering tissue regeneration and contributing to the progression of age related disorders. Here we discovered that ectopic expression of the pluripotent factor NANOG in senescent or progeroid myogenic progenitors reversed cellular aging and restored completely the ability to generate contractile force. To elicit its effects, NANOG enabled reactivation of the ROCK and Transforming Growth… Expand
NANOG Restores Contractility of Mesenchymal Stem Cell-Based Senescent Microtissues.
TLDR
The results show that NANOG could reverse the effects of stem cell senescence and restore the myogenic differentiation potential of senescent MSCs and may enable development of novel strategies to restore the function ofSenescent cardiovascular and other SMC-containing tissues. Expand
Restoring extracellular matrix synthesis in senescent stem cells
  • Na Rong, P. Mistriotis, +6 authors S. Andreadis
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2019
TLDR
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