• Corpus ID: 235790472

NANOG/GATA6 Interactions Revisited: A Statistical Mechanics Approach towards Cell Fate Decisions

  title={NANOG/GATA6 Interactions Revisited: A Statistical Mechanics Approach towards Cell Fate Decisions},
  author={Simon Schardt and Sabine C. Fischer},
In preimplantation mammalian embryos, the second cell fate decision introduces spatial patterns of embryonic and extra-embryonic precursor cells. The transcription factors NANOG and GATA6 are the earliest markers for the two cell types and interact between cells via the fibroblast growth factor signaling pathway. Computational models have been used to mimic the patterns and cell type proportions found in experimental studies. However, these models are always phenomenological in nature and lack… 

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