NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance

@article{Li2016NAMPTKA,
  title={NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance},
  author={Shengbing Li and Cong Wang and Ke Li and Lingou Li and Mingyuan Tian and Jing Xie and Mengliu Yang and Yanjun Jia and Junying He and Lingyan Gao and Guenther H. Boden and Hua Liu and Gangyi Yang},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
NAMPT has been suggested association with atherosclerosis and insulin resistance. However, the impact of NAMPT on atherosclerosis remained unknown. Therefore, the objective of this study was to use a NAMPT loss-of-function approach to investigate the effect of NAMPT on atherosclerosis in hypercholesterolemic mice. We demonstrated that a specific NAMPT knockdown increased plasma HDL-C levels, reduced the plaque area of the total aorta en face and the cross-sectional aortic sinus, decreased… 
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