NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance

@article{Li2016NAMPTKA,
  title={NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance},
  author={Shengbing Li and Cong Wang and Ke Li and Lingou Li and Mingyuan Tian and Jing Xie and Mengliu Yang and Yanjun Jia and Junying He and Lingyan Gao and Guenther H. Boden and Hua Liu and Gangyi Yang},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
NAMPT has been suggested association with atherosclerosis and insulin resistance. However, the impact of NAMPT on atherosclerosis remained unknown. Therefore, the objective of this study was to use a NAMPT loss-of-function approach to investigate the effect of NAMPT on atherosclerosis in hypercholesterolemic mice. We demonstrated that a specific NAMPT knockdown increased plasma HDL-C levels, reduced the plaque area of the total aorta en face and the cross-sectional aortic sinus, decreased… 
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Dan-hong injection (DHI) treatment attenuates atherosclerosis and macrophage lipid accumulation by promoting the activation of PI3K/AKT insulin signaling pathway and provides new insights into the molecular mechanism of DHI and its therapeutic potential in the treatment of Atherosclerosis.
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The results of this study highlight the functional dichotomy of intracellular versus extracellular NAMPT, and unveils a critical role for the iNAMPT–peroxisome proliferator–activated receptor &ggr; axis in atherosclerosis.
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The findings suggested that NAMPT is involved in the pathogenesis of atherosclerosis; the increased expression of eNAMPT in ACS patients may play a protective role by the up regulation of the NAM PT/NAD+/Sirt1 signaling pathway.
G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE-/- mice.
NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice
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It is shown that ethanol treatment suppresses the expression of Nampt in hepatocytes and that SIRT1 is required to mediate the effects of NAMPT on reduction of hepatic TG accumulation and serum ALT, AST levels in ethanol-fed mice.
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In vivo evidence is provided that Nampt transgene aggravates atherosclerotic inflammation and promotes atherosclerosis development in ApoE−/− mice.
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The versatile functions of various adipokines in atherosclerosis are reviewed and these respective functions are divided into three major groups: protective, deteriorative, and undefined.
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IFN and STAT1-inducible Nampt is identified as an important factor that shapes the metabolic program and function of tumor associated macrophages and correlates with IFNγ responses and melanoma patient survival.
Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases
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Recent experimental evidence illustrating that increasing NAD+ bioavailability, particularly by the use of natural NAD+ precursors, may offer hope for new therapeutic strategies to prevent and treat cardiovascular diseases is reviewed and discussed.
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