NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+–sirtuin-1–dependent pathway

@article{Skokowa2009NAMPTIE,
  title={NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+–sirtuin-1–dependent pathway},
  author={Julia Skokowa and Dan Lan and Basant Kumar Thakur and Fenghua Wang and Kshama Gupta and Gunnar Cario and Annette M{\"u}ller Brechlin and Axel Schambach and Lars Hinrichsen and Gundela Meyer and Matthias Gaestel and Martin Stanulla and Qiang Qiang Tong and Karl Welte},
  journal={Nature Medicine},
  year={2009},
  volume={15},
  pages={151-158}
}
We identified nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B cell colony enhancing factor (PBEF), as an essential enzyme mediating granulocyte colony-stimulating factor (G-CSF)-triggered granulopoiesis in healthy individuals and in individuals with severe congenital neutropenia. Intracellular NAMPT and NAD+ amounts in myeloid cells, as well as plasma NAMPT and NAD+ levels, were increased by G-CSF treatment of both healthy volunteers and individuals with congenital… CONTINUE READING

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