NALP3 is not necessary for early protection against experimental tuberculosis.

@article{Walter2010NALP3IN,
  title={NALP3 is not necessary for early protection against experimental tuberculosis.},
  author={Kerstin Walter and Christoph Hoelscher and J. -M. Tschopp and Stefan Ehlers},
  journal={Immunobiology},
  year={2010},
  volume={215 9-10},
  pages={804-11}
}
In vitro, Toll-like receptors (TLR)2, 4 and 9 as well as NOD-like receptor 2 critically determine macrophage responses to Mycobacterium tuberculosis (Mtb) infection. However, in low-dose experimental murine tuberculosis, single or multiple deficiencies in TLRs 2, 4, 9 or NOD2 have little, if any, impact on early mycobacterial growth containment, granuloma formation and survival. Here, we analyzed the relevance of NALP3, one component of the danger-signaling inflammasome, for (i) Mtb-induced… CONTINUE READING
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