NAFLD in 2017: Novel insights into mechanisms of disease progression

@article{Khan2018NAFLDI2,
  title={NAFLD in 2017: Novel insights into mechanisms of disease progression},
  author={Reenam S. Khan and Philip Noel Newsome},
  journal={Nature Reviews Gastroenterology \& Hepatology},
  year={2018},
  volume={15},
  pages={71-72}
}
  • R. KhanP. Newsome
  • Published 4 January 2018
  • Biology
  • Nature Reviews Gastroenterology & Hepatology
In 2017, there have been substantial advances in our understanding of the immunological and endocrine mechanisms of disease progression in NAFLD, paving the way for novel therapeutic strategies. 

Progress and challenges in the prevention and control of nonalcoholic fatty liver disease

The characteristics and prevalence of nonalcoholic fatty liver disease are summarized and the status of the understanding of its mechanisms and potential therapeutic targets are summarized.

POTENTIAL THERAPEUTIC TARGETS OF NAFLD IN OFFSPRINGS WITH RESPECT TO MATERNAL WESTERN TYPE DIET

Previously published datasets of nonalcoholic fatty liver disease from GEO database have been reanalyzed by applying a series of R programs based novel bioinformatics approaches, which led to the identification of certain potential NAFLD therapeutic targets.

Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives

Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and a common cause of liver cirrhosis and cancer. Akkermansia muciniphila (A. muciniphila) is a

Role of Innate lymphoid Cells in Obesity and Insulin Resistance

How ILCs in distinct metabolic organs may function to maintain metabolic homeostasis and contribute to obesity and its associated metabolic diseases is discussed.

Retained NK Cell Phenotype and Functionality in Non-alcoholic Fatty Liver Disease

The presence of disease-specific changes within circulating and tissue-resident NK cell populations, as well as within other major immune cell subsets, in patients with liver biopsy-confirmed NAFLD is explored and the importance of the local microenvironment in shaping the NK cell compartment is increased.

Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases

The correlation between oxidative stress, defective proteolysis, and metabolic diseases is discussed and an understanding of how ROS affects intracellular proteolytic systems may provide new perspectives on the development of and control of diseases.

A Low Iron Diet Protects from Steatohepatitis in a Mouse Model

A lower tissue iron level prevents accelerated progression of NAFLD to NASH, suggesting a possible therapeutic strategy in humans with the disease.

Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease

MAM-targeting drugs and compounds, most of which achieve their therapeutic or ameliorative effects on NAFLD by improving MAM integrity, are summarized and targeting MAMs may be a viable strategy forNAFLD treatment.

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