NAFLD and diabetes mellitus

  title={NAFLD and diabetes mellitus},
  author={Herbert Tilg and Alexander R. Moschen and Michael Roden},
  journal={Nature Reviews Gastroenterology \&Hepatology},
The liver constitutes a key organ in systemic metabolism, contributing substantially to the development of insulin resistance and type 2 diabetes mellitus (T2DM). The mechanisms underlying these processes are not entirely understood, but involve hepatic fat accumulation, alterations of energy metabolism and inflammatory signals derived from various cell types including immune cells. Lipotoxins, mitochondrial function, cytokines and adipocytokines have been proposed to play a major part in both… 

Potential Nexus of Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Insulin Resistance Between Hepatic and Peripheral Tissues

This review aims to illuminate current insights regarding the complex and strong association between NAFLD and T2DM and summarize novel and emerging targets for the treatment of hepatic insulin resistance based on established mechanistic knowledge.

Metabolic liver disease in diabetes – From mechanisms to clinical trials

Non-Alcoholic Fatty Liver Disease and Its Association With Diabetes Mellitus

This review aims to shed some light on the intricate relationship between NAFLD and T2DM and how IR links both diseases and to raise awareness among clinicians about this relationship and how the presence of one disease should raise a high index of suspicion for the existence of the other.

Role of Insulin Resistance in MAFLD

An overview of the factors contributing to and the role of systemic and local insulin resistance in the development and progression of MAFLD is provided.

When Sugar Reaches the Liver: Phenotypes of Patients with Diabetes and NAFLD

Despite the high rate of patients with T2DM and other diabetes phenotypes that can alter liver metabolism and consequently develop steatosis, fibrosis, and cirrhosis, NALFD screening is not still implemented in the daily care routine, and a clinical algorithm created around a simple, non-invasive, cost-effective model would identify high-risk patients.

Role of Mitochondria in the Liver Metabolism in Obesity and Type 2 Diabetes

Metabolic Changes of Hepatocytes in NAFLD

A detailed summary of the metabolic characteristics of hepatocytes in the context of NAFLD helps to better understand the pathogenesis and outcomes of the disease.

Role of 2-series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non-alcoholic fatty liver disease (Review)

In the present review, the role of 2-series PGs in the highly intertwined pathogenic mechanisms of T2DM and NAFLD was discussed, and important therapeutic strategies based on targeting 2- series PG pathways in T2 DM andNAFLD treatment were provided.

The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease

The molecular mechanisms of inflammation and hepatic fibrosis in IR are described, the relationship between T2DM and hepatocellular carcinoma in patients with NAFLD is described, and the relationship Between T2 DM and HCC in patientswith NAFLd is described.

Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective

  • E. Rhee
  • Medicine
    Endocrinology and metabolism
  • 2019
Current epidemiological data on the associations between NAFLD and T2DM are discussed, and how each disease affects the course of the other is discussed.



Mechanisms of Disease: hepatic steatosis in type 2 diabetes—pathogenesis and clinical relevance

  • M. Roden
  • Medicine, Biology
    Nature Clinical Practice Endocrinology &Metabolism
  • 2006
Liver fat is a critical determinant of metabolic fluxes and inflammatory processes, thereby representing an important therapeutic target in insulin resistance and type 2 diabetes mellitus.

Nonalcoholic Fatty Liver: A Possible New Target for Type 2 Diabetes Prevention and Treatment

Overall, available data suggest that metformin has beneficial effects on body weight reduction and metabolic parameters, with uncertain effects on liver histology, while pioglitazone may improve liver Histology.

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Data show that hepatic DAG content in lipid droplets is the best predictor of insulin resistance in humans, and they support the hypothesis that NAFLD-associated hepatic insulin resistance is caused by an increase in hepaticDAG content, which results in activation of PKCε.

Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis.

Current evidence linking obesity, NAFLD and liver cancer is summarized, its clinical impact is discussed, and the main mechanisms underlying this complex relationship are described.

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease.

This review discusses recent clinical and diagnostic methods assessing NAFLD diagnosis, progression, and outcomes; compares the features of genetic and dietary animal models ofNAFLD; and highlights pharmacological approaches for disease treatment.

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The mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease are analyzed.

Inflammatory Mechanisms in the Regulation of Insulin Resistance

As a complex network of inflammatory cytokines, adipocytokines, transcription factors, receptor molecules, and acute-phase reactants are involved in the development of IR, new therapeutic approaches in IR-related diseases will be based on a better understanding of their complex interactions.

NAFLD: a multisystem disease.

High Prevalence of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus and Normal Plasma Aminotransferase Levels.

The prevalence of NAFLD is much higher than previously believed in overweight/obese patients with T2DM and normal aminotransferases, and many are at increased risk of severe liver disease (NASH).