NAFLD and diabetes mellitus

@article{Tilg2017NAFLDAD,
  title={NAFLD and diabetes mellitus},
  author={Herbert Tilg and Alexander R. Moschen and Michael Roden},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  year={2017},
  volume={14},
  pages={32-42}
}
The liver constitutes a key organ in systemic metabolism, contributing substantially to the development of insulin resistance and type 2 diabetes mellitus (T2DM). The mechanisms underlying these processes are not entirely understood, but involve hepatic fat accumulation, alterations of energy metabolism and inflammatory signals derived from various cell types including immune cells. Lipotoxins, mitochondrial function, cytokines and adipocytokines have been proposed to play a major part in both… 

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