NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

@article{Sahoo2016NADPHOK,
  title={NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?},
  author={Sanghamitra Sahoo and Daniel N. Meijles and Patrick J Pagano},
  journal={Clinical science},
  year={2016},
  volume={130 5},
  pages={317-35}
}
Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF). NADPH oxidases (Nox) are a major source of ROS in the vasculature and are key players in mediating redox signalling under physiological and pathophysiological conditions. In this review, we focus on the Nox-mediated ROS signalling pathways involved in the regulation of 'longevity genes' and… CONTINUE READING