NADPH oxidases: an overview from structure to innate immunity-associated pathologies

  title={NADPH oxidases: an overview from structure to innate immunity-associated pathologies},
  author={Arvind Panday and Malaya K. Sahoo and Diana S Osorio and Sanjay Batra},
  journal={Cellular and Molecular Immunology},
Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are lethal to cells, and the overproduction of these molecules leads to a myriad of devastating diseases. The key producers of ROS in many cells are the NOX family of NADPH oxidases, of which there are seven members, with various tissue distributions and activation mechanisms. NADPH oxidase is a multisubunit enzyme comprising… CONTINUE READING
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