NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa.

@article{Usui2009NADPHOP,
  title={NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa.},
  author={Shinichi Usui and Brian C. Oveson and Sun Young Lee and Young-Joon Jo and Tsunehiko Yoshida and Akiko Miki and Katsuaki Miki and Takeshi Iwase and Lili Lu and Peter Anthony Campochiaro},
  journal={Journal of neurochemistry},
  year={2009},
  volume={110 3},
  pages={1028-37}
}
Retinitis pigmentosa (RP) is a collection of diseases in which rod photoreceptors die from a variety of mutations. After rods die, the level of tissue oxygen in the outer retina becomes elevated and there is progressive oxidative damage to cones that ultimately triggers apoptosis. In this study, we investigated the hypothesis that NADPH oxidase (Nox) and/or xanthine oxidase serve as critical intermediaries between increased tissue oxygen and the generation of excessive reactive oxygen species… CONTINUE READING