NADPH oxidase of neutrophils elevates o,o'-dityrosine cross-links in proteins and urine during inflammation.

Reactive intermediates generated by phagocytic white blood cells are of central importance in destroying microorganisms, but they may also damage normal tissue at sites of inflammation. To investigate the potential role of such oxidants in tissue injury, we used gas chromatography/mass spectrometry to quantify levels of o,o'-dityrosine in mouse peritoneal… CONTINUE READING