NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

@inproceedings{Li2010NADPHOL,
  title={NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis},
  author={Gang Li and Christopher M Scull and Lale Ozcan and Ira Tabas},
  booktitle={The Journal of cell biology},
  year={2010}
}
Endoplasmic reticulum (ER)-induced apoptosis and oxidative stress contribute to several chronic disease processes, yet molecular and cellular mechanisms linking ER stress and oxidative stress in the setting of apoptosis are poorly understood and infrequently explored in vivo. In this paper, we focus on a previously elucidated ER stress-apoptosis pathway whose molecular components have been identified and documented to cause apoptosis in vivo. We now show that nicotinamide adenine dinucleotide… CONTINUE READING
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