NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage.

@article{Chiriac2007NADPHOI,
  title={NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage.},
  author={Mircea Teodor Chiriac and Joachim Roesler and Anca Sindrilaru and Karin Scharffetter-Kochanek and Detlef Zillikens and Cassian Sitaru},
  journal={The Journal of pathology},
  year={2007},
  volume={212 1},
  pages={56-65}
}
The contribution of phagocyte-derived reactive oxygen species to tissue injury in autoimmune inflammatory diseases is unclear. Here we report that granulocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase crucially contributes to tissue injury in experimental models of the antibody-mediated autoimmune disease epidermolysis bullosa acquisita. Neutrophil cytosolic factor 1-deficient mice lacking functional NADPH oxidase were resistant to skin blistering by the passive transfer of… CONTINUE READING

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