NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease.

@article{Dhiman2011NADPHOI,
  title={NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease.},
  author={Monisha Dhiman and Nisha Jain Garg},
  journal={The Journal of pathology},
  year={2011},
  volume={225 4},
  pages={
          583-96
        }
}
Trypanosoma cruzi, the aetiological agent of Chagas disease, invades nucleated mammalian cells including macrophages. In this study, we investigated the crosstalk between T. cruzi-induced immune activation of reactive oxygen species (ROS) and pro-inflammatory responses, and their role in myocardial pathology. Splenocytes of infected mice (C3H/HeN) responded to Tc-antigenic stimulus by more than a two-fold increase in NADPH oxidase (NOX) activity, ROS generation, cytokine production (IFN-γ > IL… CONTINUE READING
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