NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents

  title={NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents},
  author={Olubukola Babalola and Andrew Mamalis and Hadar A Lev-Tov and Jared R. Jagdeo},
  journal={Archives of Dermatological Research},
Fibrosis is characterized by the excessive deposition of extracellular matrix components eventually resulting in organ dysfunction and failure. In dermatology, fibrosis is the hallmark component of many skin diseases, including systemic sclerosis, graft-versus-host disease, hypertrophic scars, keloids, nephrogenic systemic fibrosis, porphyria cutanea tarda, restrictive dermopathy and other conditions. Fibrotic skin disorders may be debilitating and impair quality of life. There are few FDA… CONTINUE READING
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