NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways.

@article{Abid2007NADPHOA,
  title={NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways.},
  author={Md Ruhul Abid and Katherine C. Spokes and Shou-Ching Shih and William C. Aird},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 48},
  pages={35373-85}
}
Vascular endothelial growth factor (VEGF) and reactive oxygen species (ROS) play critical roles in vascular physiology and pathophysiology. We have demonstrated previously that NADPH oxidase-derived ROS are required for VEGF-mediated migration and proliferation of endothelial cells. The goal of this study was to determine the extent to which VEGF signaling is coupled to NADPH oxidase activity. Human umbilical vein endothelial cells and/or human coronary artery endothelial cells were transfected… CONTINUE READING