NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium.

@article{Wang2011NADPHOA,
  title={NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium.},
  author={Xin Wang and Young-Ok Son and Qingshan Chang and Lijuan Sun and John Andrew Hitron and Amit Budhraja and Zhuo Zhang and Zunji Ke and Erwei Song and Jia Luo and Xianglin Shi},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2011},
  volume={123 2},
  pages={399-410}
}
Hexavalent chromium [Cr(VI)] is a well-known human carcinogen associated with the incidence of lung cancer. Although overproduction of reactive oxygen species (ROS) has been suggested to play a major role in its carcinogenicity, the mechanisms of Cr(VI)-induced ROS production remain unclear. In this study, we investigated the role of NADPH oxidase (NOX), one of the major sources of cellular ROS, in Cr(VI)-induced oxidative stress and carcinogenesis. We found that short-term exposure to Cr(VI… CONTINUE READING
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