NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases.

@article{Jos2008NADPHOC,
  title={NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases.},
  author={Gorka San Jos{\'e} and Ana Fortu{\~n}o and Oscar Beloqui and Javier D{\'i}ez and Guillermo Zalba},
  journal={Clinical science},
  year={2008},
  volume={114 3},
  pages={
          173-82
        }
}
Oxidative stress plays a key role in the pathophysiology of several major cardiovascular diseases, including atherosclerosis, hypertension, heart failure, stroke and diabetes. ROS (reactive oxygen species) affect multiple tissues either directly or through NO depletion. ROS induce cardiovascular dysfunction by modulating cell contraction/dilation, migration, growth/apoptosis and extracellular matrix protein turnover, which contribute to vascular and cardiac remodelling. Of the several sources… CONTINUE READING

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