NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury.

@article{KallenbornGerhardt2012NADPHOM,
  title={NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury.},
  author={Wiebke Kallenborn-Gerhardt and Katrin Schroeder and Domenico Del Turco and Ruirui Lu and Katharina Kynast and Judith Kosowski and Ellen Niederberger and Ajay M. Shah and Ralf Peter Brandes and Gerd Geisslinger and Achim Schmidtko},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 30},
  pages={10136-45}
}
Reactive oxygen species (ROS) contribute to sensitization of pain pathways during neuropathic pain, but little is known about the primary sources of ROS production and how ROS mediate pain sensitization. Here, we show that the NADPH oxidase isoform Nox4, a major ROS source in somatic cells, is expressed in a subset of nonpeptidergic nociceptors and myelinated dorsal root ganglia neurons. Mice lacking Nox4 demonstrated a substantially reduced late-phase neuropathic pain behavior after peripheral… CONTINUE READING

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