NADPH oxidase 4 function as a hydrogen peroxide sensor.

  title={NADPH oxidase 4 function as a hydrogen peroxide sensor.},
  author={Yukio Nisimoto and Hisamitsu Ogawa and Yuzo Kadokawa and Shanlou Qiao},
  journal={Journal of biochemistry},
  volume={163 6},
Nox4, a member of the NADPH- and oxygen-dependent oxidoreductases that generate reactive oxygen species (ROS), is widely expressed and constitutively active. To understand better its function and regulation, specific mutations in the Nox4 dehydrogenase (DH) domain were examined for effects on Nox4 oxidase activity. Transfection of His6-tagged Nox4 increased the amount of p22phox subunit in HEK293 cells, and a higher level of the heterodimer was observed in the nucleus-enriched fraction (NEF… CONTINUE READING
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